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What should I discuss with my healthcare provider before I receive Myobloc (Myobloc)?

You should not receive this medication if you are allergic to botulinum toxin, or if you have a skin infection in the area where the medicine will be injected. Tell your doctor if you have ever had a side effect after receiving botulinum toxin in the past.

If you have any of these other conditions, you may need a dose adjustment or special tests:

• amyotrophic lateral sclerosis (ALS, or "Lou Gehrig's disease");
• myasthenia gravis;
• Lambert-Eaton syndrome;
• a breathing problem such as asthma or emphysema;
• problems with swallowing;
• bleeding problems;
• if you are planning to have surgery; or
• if you have ever received other botulinum toxin injections such as Botox or Dysport (especially in the last 4 months).

Myobloc is made using human plasma (part of the blood) and may contain viruses and other infectious agents that can cause disease. Although donated human plasma is screened, tested, and treated to reduce the risk of it containing anything that could cause disease, there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

FDA pregnancy category C. It is not know whether botulinum toxin is harmful to an unborn baby. Before you receive this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether botulinum toxin passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

How is Myobloc given (Myobloc)?

This medication is injected into a muscle. A doctor, nurse, or other healthcare provider will give you this injection. Myobloc injections should be spaced at least 3 months apart.

Your injection may be given into more than one area at a time, depending on the condition being treated.

The effects of a botulinum toxin injection are temporary. Your symptoms may return completely within 3 months after an injection. After repeat injections, it may take less and less time before your symptoms return, especially if your body develops antibodies to the botulinum toxin.

Do not seek botulinum toxin injections from more than one medical professional at a time. If you switch healthcare providers, be sure to tell your new provider how long it has been since your last botulinum toxin injection.

Using this medication more often than prescribed will not make it more effective and may result in serious side effects.

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