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Medications and Drugs

Brand Names: EndaCof-AC, Nalex AC

Generic Name: brompheniramine and codeine (Pronunciation: BROM fen IR a meen and KOE deen)

What is brompheniramine and codeine (EndaCof-AC, Nalex AC)?

Brompheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Codeine is a narcotic cough suppressant. It affects the signals in the brain that trigger cough reflex.

The combination of brompheniramine and codeine is used to treat runny nose, sneezing, itching, watery eyes, and cough caused by allergies, the common cold, or the flu.

Brompheniramine and codeine may also be used for purposes not listed in this medication guide.

What are the possible side effects of brompheniramine and codeine (EndaCof-AC, Nalex AC)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking the medication and call your doctor at once if you have a serious side effect such as:

  • confusion, mood changes, hallucinations, unusual thoughts or behavior;
  • severe dizziness or drowsiness, feeling like you might pass out;
  • severe nervousness, fast or uneven heart rate, tremor, seizure (convulsions);
  • severe stomach cramps or constipation;
  • urinating less than usual or not at all;
  • pain or numbness in the arms or legs;
  • easy bruising or bleeding, unusual weakness; or
  • weak or shallow breathing.

Less serious side effects may include:

  • blurred vision;
  • dizziness, drowsiness, tired feeling;
  • dry mouth, nose, or throat;
  • nausea, vomiting, constipation; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about brompheniramine and codeine (EndaCof-AC, Nalex AC)?

You should not use this medication if you have severe liver disease, inflammatory bowel disease, severe constipation, a blockage in your stomach or intestines, severe colitis or toxic megacolon, if you have a colostomy or ileostomy, if you are unable to urinate, if you have been sick with diarrhea, if you recently drank large amounts of alcohol, or if you have a head injury or brain tumor.

Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, or overactive thyroid.

Do not use this medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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