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Medications and Drugs

Brand Names: Bromhist-DM, Histacol DM Pediatric Syrup, Pediahist DM Syrup

Generic Name: brompheniramine, dextromethorphan, guaifenesin, and pseudoephedrine (Pronunciation: brom fen EER a meen, DEX tro me THOR fan, gwye FEN e sin, SOO doe ee FED rin)

What is brompheniramine, dextromethorphan, guaifenesin, and pseudoephedrine (Bromhist-DM, Histacol DM Pediatric Syrup, Pediahist DM Syrup)?

Brompheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of brompheniramine, dextromethorphan, guaifenesin, and pseudoephedrine is used to treat sneezing, runny or stuffy nose, cough, chest congestion, itchy or watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold.

Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.

Brompheniramine, dextromethorphan, guaifenesin, and pseudoephedrine may also be used for purposes not listed in this medication guide.

What are the possible side effects of brompheniramine, dextromethorphan, guaifenesin, and pseudoephedrine (Bromhist-DM, Histacol DM Pediatric Syrup, Pediahist DM Syrup)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • fast, pounding, or uneven heartbeat;
  • slow, shallow breathing;
  • confusion, hallucinations, unusual thoughts or behavior;
  • severe dizziness, anxiety, restless feeling, or nervousness;
  • increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);
  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms; or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • dry mouth;
  • nausea, stomach pain, constipation, mild loss of appetite, upset stomach;
  • blurred vision;
  • warmth, tingling, or redness under your skin;
  • sleep problems (insomnia);
  • feeling restless or excited (especially in children);
  • skin rash or itching;
  • dizziness, drowsiness, or headache;
  • problems with memory or concentration; or
  • ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about brompheniramine, dextromethorphan, guaifenesin, and pseudoephedrine (Bromhist-DM, Histacol DM Pediatric Syrup, Pediahist DM Syrup)?

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Ask a doctor or pharmacist before using any other cough, cold, allergy, or sleep medication. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine, decongestant, expectorant, or cough suppressant.

This medication impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.

Drinking alcohol can increase certain side effects of brompheniramine, dextromethorphan, guaifenesin, and pseudoephedrine.

Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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