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Medications and Drugs

Brand Names: AccuHist PDX Syrup, Allanhist PDX Syrup, Bromhist-PDX, EndaCof-PD

Generic Name: brompheniramine, dextromethorphan, guaifenesin, and phenylephrine (Pronunciation: brom fen EER a meen, dex tro me THOR fan, gwye FEN e sin, fen il EFF rin)

What is brompheniramine, dextromethorphan, guaifenesin, and phenylephrine (AccuHist PDX Syrup, Allanhist PDX Syrup, Bromhist-PDX, EndaCof-PD)?

Brompheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of brompheniramine, dextromethorphan, guaifenesin, and phenylephrine is used to treat runny or stuffy nose, sneezing, itching, watery eyes, cough, chest congestion, and sinus congestion caused by allergies, the common cold, or the flu.

Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.

Brompheniramine, dextromethorphan, guaifenesin, and phenylephrine may also be used for purposes not listed in this medication guide.

What are the possible side effects of this medicine (AccuHist PDX Syrup, Allanhist PDX Syrup, Bromhist-PDX, EndaCof-PD)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have a serious side effect such as:

  • fast, slow, or uneven heart rate;
  • severe dizziness or anxiety, feeling like you might pass out;
  • mood changes, confusion, agitation, behavior changes, hallucinations, feelings of extreme happiness;
  • severe headache, tremor, seizure (convulsions);
  • easy bruising or bleeding, unusual weakness;
  • urinating less than usual or not at all;
  • fever, feeling short of breath; or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, chest pain, uneven heartbeats, seizure).

Less serious side effects may include:

  • mild dizziness or drowsiness;
  • mild headache;
  • dry mouth, nose, or throat;
  • constipation, diarrhea, upset stomach;
  • blurred vision;
  • sleep problems (insomnia); or
  • feeling nervous, restless, anxious, or irritable.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about this medicine (AccuHist PDX Syrup, Allanhist PDX Syrup, Bromhist-PDX, EndaCof-PD)?

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

You should not use this medication if you have severe constipation, a blockage in your stomach or intestines, or if you are unable to urinate.

Do not use cough or cold medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, high blood pressure, heart disease, coronary artery disease, or overactive thyroid.

Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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