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busulfan (cont.)

What should I discuss with my healthcare provider before using busulfan (Busulfex, Myleran)?

You should not use busulfan if you are allergic to it.

To make sure you can safely take busulfan, tell your doctor if you have any of these other conditions:

  • a weak immune system (bone marrow depression) caused by other cancer medications or radiation treatment;
  • epilepsy or other seizure disorder;
  • history of head injury; or
  • a history of lung or breathing problems.

FDA pregnancy category D. Do not use busulfan if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

This medication may affect fertility (your ability to have children), whether you are a man or a woman.

It is not known whether busulfan passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Some people treated with busulfan have developed new forms of cancer. Talk to your doctor about your specific risks and benefits of using this medication.

How should I use busulfan (Busulfex, Myleran)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Take the busulfan tablet with a full glass of water.

Busulfan injection is given through a needle placed into a vein in your upper chest (central IV). You will receive this injection in a clinic or hospital setting. You will also receive other medications to help prevent certain side effects of busulfan.

Busulfan injection is usually given every 6 hours for 4 days in a row. The medicine must be given slowly through the IV, and each infusion can take at least 2 hours to complete.

Busulfan can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill.

To be sure your blood cells do not get too low, your blood will need to be tested on a weekly or monthly basis. Your liver function may also need to be tested on a regular basis. Busulfan can have long-lasting effects on your body. Do not miss any follow-up visits to your doctor for blood or urine tests.

Contact your doctor at once if you develop signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), weight loss, mouth sores, or unusual weakness.

Store busulfan tablets at room temperature away from moisture and heat.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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