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Medications and Drugs

Brand Names: C-Tanna 12, Tannate 12 S, Tannic-12 S, Trionate, Tussi-12, Tussi-12S, Tussizone-12 RF, Tustan 12S

Generic Name: carbetapentane and chlorpheniramine (Pronunciation: kar BET a PEN tane and KLOR fen IR a meen)

What is carbetapentane and chlorpheniramine (C-Tanna 12, Tannate 12 S, Tannic-12 S, Trionate, Tussi-12, Tussi-12S, Tussizone-12 RF, Tustan 12S)?

Carbetapentane is a cough suppressant.

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

The combination of carbetapentane and chlorpheniramine is used to treat runny nose, sneezing, watery eyes, and cough caused by allergies, the common cold, or the flu.

This medication will not treat a cough that is caused by smoking, asthma, or emphysema.

Carbetapentane and chlorpheniramine may also be used for other purposes not listed in this medication guide.


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What are the possible side effects of carbetapentane and chlorpheniramine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • fast, pounding, or uneven heartbeat;
  • confusion, unusual thoughts or behavior, seizure (convulsions);
  • severe dizziness, anxiety, restless feeling, or nervousness;
  • urinating less than usual or not at all; or
  • slow, shallow breathing.

Less serious side effects may include:

  • dizziness, drowsiness;
  • blurred vision;
  • dry mouth, nose, or eyes; or
  • nausea, stomach pain, constipation, loss of appetite.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about carbetapentane and chlorpheniramine?

Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Before using this medication, tell your doctor if you have heart disease, high blood pressure, emphysema, chronic bronchitis, a seizure disorder, glaucoma, kidney disease, a thyroid disorder, enlarged prostate, problems with urination, or any drug or food allergies.

Avoid drinking alcohol while you are taking carbetapentane and chlorpheniramine.

Do not use any other over-the-counter cough, cold, allergy, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains an antihistamine or cough suppressant.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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