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Medications and Drugs

Brand Names: Corzall Plus, Zotex-D

Generic Name: carbetapentane, pseudoephedrine, and pyrilamine (Pronunciation: kar BET a PEN tane SOO doe ee FED rin, pir IL a meen)

What is carbetapentane, pseudoephedrine, and pyrilamine (Corzall Plus, Zotex-D)?

Carbetapentane is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Pyrilamine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

The combination of carbetapentane, pseudoephedrine, and pyrilamine is used to treat runny nose, sneezing, cough, watery eyes, and itching caused by allergies, the common cold, or flu.

This medication will not treat a cough that is caused by smoking, asthma, or emphysema.

Carbetapentane, pseudoephedrine, and pyrilamine may also be used to treat other conditions not listed in this medication guide.

What are the possible side effects of carbetapentane, pseudoephedrine, and pyrilamine (Corzall Plus, Zotex-D)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • confusion, hallucinations, tremors;
  • seizure (confusion);
  • extreme weakness;
  • feeling like you might pass out;
  • fast, slow, or uneven heart rate; or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • drowsiness, dizziness;
  • headache;
  • dryness in your mouth, nose, or throat;
  • nausea; or
  • warmth, redness, or tingly feeling under your skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about carbetapentane, pseudoephedrine, and pyrilamine (Corzall Plus, Zotex-D)?

You should not use this medication if you are allergic to carbetapentane, pseudoephedrine, pyrilamine.

Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

Before you take carbetapentane, pseudoephedrine, and pyrilamine, tell your doctor if you have asthma or other breathing disorder, heart disease, high blood pressure, glaucoma, diabetes, liver or kidney disease, urination problems, a seizure disorder, stomach ulcer or intestinal blockage, or an overactive thyroid.

Also tell your doctor about all other medications you use.

This medication can cause side effects that may cause drowsiness, dizziness, or blurred vision. Be careful if you drive or do anything that requires you to be alert and able to see clearly.

Avoid drinking alcohol. It can increase some of the side effects of carbetapentane, pseudoephedrine, and pyrilamine.

Talk with your doctor if your symptoms do not improve after 7 days of taking this medication. Call your doctor any time if your symptoms get worse or if you also have a fever, headache, or skin rash.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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