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Medications and Drugs

Brand Names: Evoxac

Generic Name: cevimeline (Pronunciation: se vi ME leen)

What is cevimeline (Evoxac)?

Cevimeline increases the secretions of the saliva and sweat glands in the body.

Cevimeline is used to treat dry mouth in people with Sjogren's Syndrome.

Cevimeline may also be used for other purposes not listed in this medication guide.

What are the possible side effects of cevimeline (Evoxac)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking cevimeline and call your doctor at once if you have any of these serious side effects:

  • shortness of breath, wheezing, or tightness in your chest;
  • chest pain, uneven heart rate;
  • attacks of severe stomach pain on the right side, extending up to your shoulder (sometimes worse after meals);
  • nausea and vomiting, bloating, fever, chills, and jaundice (yellowing of the skin or eyes);
  • swelling in your hands or feet;
  • eye pain or drainage;
  • fever, ear ache, flu symptoms; or
  • white patches or sores inside your mouth or on your lips.

Less serious side effects may include:

  • blurred vision, dry eyes;
  • excessive sweating or salivating, drooling;
  • runny or stuffy nose;
  • nausea, diarrhea, constipation, loss of appetite;
  • dry mouth;
  • muscle pain;
  • vaginal itching or discharge;

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about cevimeline (Evoxac)?

Do not take this medication if you are allergic to cevimeline, or if you have untreated or uncontrolled asthma, glaucoma, or an eye condition called iritis or uveitis.

Before taking cevimeline, tell your doctor if you have heart disease, heart rhythm disorder, angina (chest pain), or a history of heart attack, high blood pressure (hypertension), asthma or other breathing disorder, or a history of kidney or gall stones.

Cevimeline can cause side effects that may impair your vision, especially at night. Be careful if you drive or do anything that requires you to be able to see clearly.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Cevimeline may cause excessive sweating and you may get dehydrated more easily while taking this medication. Follow your doctor's instructions about the type and amount of liquids you should drink.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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