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Medications and Drugs

Brand Names: Codar AR, Cotab A, Cotab AX, Endacof-C, Notuss-AC, TL-Hist CM, Zodryl AC 25, Zodryl AC 30, Zodryl AC 35, Zodryl AC 40, Zodryl AC 50, Zodryl AC 60, Zodryl AC 80, Zodryl AC Adult, Z-Tuss AC

Generic Name: chlorpheniramine and codeine (Pronunciation: KLOR fen IR a meed and KOE deen)

What is chlorpheniramine and codeine (Codar AR, Cotab A, Cotab AX, Endacof-C, Notuss-AC, TL-Hist CM, Zodryl AC 25, Zodryl AC 30, Zodryl AC 35, Zodryl AC 40, Zodryl AC 50, Zodryl AC 60, Zodryl AC 80, Zodryl AC Adult, Z-Tuss AC)?

Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Codeine is a narcotic cough suppressant. It affects the signals in the brain that trigger cough reflex.

The combination of chlorpheniramine and codeine is used to treat runny nose, sneezing, itching, watery eyes, and cough caused by allergies, the common cold, or the flu.

Chlorpheniramine and codeine will not treat a cough that is caused by smoking, asthma, or emphysema.

Chlorpheniramine and codeine may also be used for purposes not listed in this medication guide.

What are the possible side effects of chlorpheniramine and codeine?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using chlorpheniramine and codeine and call your doctor at once if you have a serious side effect such as:

  • confusion, mood changes, hallucinations, unusual thoughts or behavior;
  • severe dizziness or drowsiness, feeling like you might pass out;
  • severe nervousness, fast or uneven heart rate, tremor, seizure (convulsions);
  • pain or numbness in the arms or legs;
  • severe stomach cramps or constipation;
  • weak or shallow breathing;
  • easy bruising or bleeding, unusual weakness; or
  • urinating less than usual or not at all.

Less serious side effects may include:

  • dizziness, drowsiness, tired feeling;
  • dry mouth, nose, or throat;
  • blurred vision;
  • nausea, vomiting, constipation; or
  • sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about chlorpheniramine and codeine?

You should not use this medicine if you have severe liver disease, inflammatory bowel disease, severe constipation, a blockage in your stomach or intestines, severe colitis or toxic megacolon, if you have a colostomy or ileostomy, if you are unable to urinate, if you have been sick with diarrhea, if you recently drank large amounts of alcohol, or if you have a head injury or brain tumor.

Do not use this medicine if you have untreated or uncontrolled diseases such as glaucoma, asthma or COPD, heart disease, or a thyroid disorder.

Do not use a cough or cold medicine if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Codeine puede crear dependencia, y solamente debe ser usada por la persona para quien ha sido recetada. Mantenga la medicina en un lugar seguro donde otros no la puedan obtener.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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