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Medications and Drugs

Brand Names: Advil Allergy Sinus, Advil Childrens Allergy Sinus, Advil Multi-Symptom Cold

Generic Name: chlorpheniramine, ibuprofen, and pseudoephedrine (Pronunciation: KLOR fen EER a meen, EYE bue pro fen, SOO doe ee FED rin)

What is chlorpheniramine, ibuprofen, and pseudoephedrine (Advil Allergy Sinus, Advil Childrens Allergy Sinus, Advil Multi-Symptom Cold)?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Ibuprofen is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of chlorpheniramine, ibuprofen, and pseudoephedrine is used to treat sneezing, itching, watery eyes, runny nose, stuffy nose, sinus congestion, headache, and pain or fever caused by allergies or the common cold.

Chlorpheniramine, ibuprofen, and pseudoephedrine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of chlorpheniramine, ibuprofen, and pseudoephedrine (Advil Allergy Sinus, Advil Childrens Allergy Sinus, Advil Multi-Symptom Cold)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives or blistering skin rash; wheezing or trouble breathing; faint; or swelling of your face, lips, tongue, or throat.

Stop taking this medication seek medical attention or call your doctor at once if you have a serious side effect such as:

  • chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
  • worsening stomach pain, black, bloody, or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • fast, pounding, or uneven heartbeat;
  • redness or swelling;
  • severe dizziness, trouble sleeping, or nervousness;
  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure);
  • urinating less than usual or not at all;
  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness; or
  • fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions).

Less serious side effects may include:

  • upset stomach, nausea, heartburn, diarrhea, constipation;
  • bloating, gas, loss of appetite;
  • warmth, tingling, or redness under your skin;
  • dizziness, headache, feeling excited or restless;
  • skin itching or rash; or
  • ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about chlorpheniramine, ibuprofen, and pseudoephedrine (Advil Allergy Sinus, Advil Childrens Allergy Sinus, Advil Multi-Symptom Cold)?

Do not give this medication to a child younger than 12 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Do not use chlorpheniramine, ibuprofen, and pseudoephedrine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

Ibuprofen can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

Ibuprofen can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning at any time while you are taking ibuprofen. Ibuprofen may be more likely to cause stomach bleeding in adults who are 60 or older.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes worsening stomach pain, black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

You should not use this medication if you are allergic to ibuprofen or pseudoephedrine, or if you have a stomach ulcer or active bleeding in your stomach or intestines, polyps in your nose, or a history of allergic reaction to aspirin or other NSAIDs.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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