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chlorpheniramine, ibuprofen, and pseudoephedrine (cont.)

What should I discuss with my doctor before taking chlorpheniramine, ibuprofen, and pseudoephedrine (Advil Allergy Sinus, Advil Childrens Allergy Sinus, Advil Multi-Symptom Cold)?

Do not use chlorpheniramine, ibuprofen, and pseudoephedrine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take chlorpheniramine, ibuprofen, and pseudoephedrine before the MAO inhibitor has cleared from your body.

Do not use this medication if you are allergic to ibuprofen or pseudoephedrine, or if you have:

  • a stomach ulcer or active bleeding in your stomach or intestines;
  • polyps in your nose; or
  • a history of allergic reaction to aspirin or other NSAIDs.

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you take this medication, tell your doctor if you have:

Taking an NSAID can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use an NSAID. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

NSAIDs can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking an NSAID. Older adults may have an even greater risk of these serious gastrointestinal side effects.

This medication may be harmful to an unborn baby. Taking ibuprofen during the last 3 months of pregnancy may result in birth defects and prolonged labor and delivery. Do not take chlorpheniramine, ibuprofen, and pseudoephedrine during the last 3 months of pregnancy unless your doctor has told you to.

Chlorpheniramine, ibuprofen, and pseudoephedrine passes into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Ibuprofen may be more likely to cause stomach bleeding in adults who are 60 or older.

Do not give this medication to a child younger than 12 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

How should I take chlorpheniramine, ibuprofen, and pseudoephedrine (Advil Allergy Sinus, Advil Childrens Allergy Sinus, Advil Multi-Symptom Cold)?

Use this medication exactly as directed on the label, or as it has been prescribed by your doctor. Do not use the medication in larger amounts, or use it for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up.

Take this medicine with food or milk if it upsets your stomach.

Do not take more of this medication than is recommended. An overdose of ibuprofen can cause damage to your stomach or intestines. The maximum amount of ibuprofen for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Use only the smallest amount of chlorpheniramine, ibuprofen, and pseudoephedrine needed to get relief from your cold or allergy symptoms.

Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Call your doctor if you have any new symptoms, or if you have a fever lasting longer than 3 days, stuffy nose lasting longer than 7 days, or pain lasting longer than 10 days. Do not take this medication for longer than 10 days without your doctor's advice.

If you need to have any type of surgery, tell the surgeon ahead of time if you have taken a cold medicine within the past few days.

This medication can cause you to have unusual results with allergy skin tests. Tell any doctor who treats you that you are taking an antihistamine.

Store this medication at room temperature away from moisture and heat.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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