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Medications and Drugs

Brand Names: C-Hist-SR, Chlortox, Comhist, Linhist-L.A., Nalex-A

Generic Name: chlorpheniramine, phenyltoloxamine, and phenylephrine (Pronunciation: klor fen IR a meen/fen ill toe LOX a meen/fen ill EFF rin)

What is chlorpheniramine, phenyltoloxamine, and phenylephrine (C-Hist-SR, Chlortox, Comhist, Linhist-L.A., Nalex-A)?

Chlorpheniramine and phenyltoloxamine are antihistamines. They block the effects of the naturally occurring chemical histamine in the body. Chlorpheniramine and phenyltoloxamine prevent sneezing; itchy, watery eyes and nose; and other symptoms of allergies and hay fever.

Phenylephrine is a decongestant. It constricts (shrinks) blood vessels (veins and arteries). This reduces the blood flow to certain areas and allows nasal passages to open up.

Chlorpheniramine, phenyltoloxamine, and phenylephrine is used to treat nasal congestion and sinusitis (inflammation of the sinuses) associated with allergies, hay fever, and the common cold.

Chlorpheniramine, phenyltoloxamine, and phenylephrine may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of chlorpheniramine, phenyltoloxamine, and phenylephrine (C-Hist-SR, Chlortox, Comhist, Linhist-L.A., Nalex-A)?

Serious side effects are unlikely to occur. Stop taking chlorpheniramine, phenyltoloxamine, and phenylephrine and seek emergency medical attention if you experience an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives).

Other, less serious side effects may be more likely to occur. Continue to take chlorpheniramine, phenyltoloxamine, and phenylephrine and talk to your doctor or try another similar medication if you experience

  • dryness of the eyes, nose, and mouth;
  • drowsiness or dizziness;
  • blurred vision;
  • difficulty urinating; or
  • excitation in children.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about chlorpheniramine, phenyltoloxamine, and phenylephrine (C-Hist-SR, Chlortox, Comhist, Linhist-L.A., Nalex-A)?

Use caution when driving, operating machinery, or performing other hazardous activities. Chlorpheniramine, phenyltoloxamine, and phenylephrine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking chlorpheniramine, phenyltoloxamine, and phenylephrine.

Do not take more of this medication than is recommended. If your symptoms do not improve, or if they worsen, talk to your doctor.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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