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Medications and Drugs

Brand Names: Cytra-3, Polycitra, Polycitra-LC, Tricitrates

Generic Name: citric acid, potassium citrate, and sodium citrate (Pronunciation: SIT rik AS id, poe TASS ee um, and SOE dee um SIT rayt)

What is citric acid, potassium citrate, and sodium citrate (Cytra-3, Polycitra, Polycitra-LC, Tricitrates)?

Citric acid and sodium citrate are alkalinizing agents that make the urine less acidic.

Potassium is a mineral that is found in many foods and is needed for several functions of your body, especially the beating of your heart.

The combination of citric acid, potassium citrate, and sodium citrate is used to prevent gout or kidney stones, or metabolic acidosis in people with kidney problems.

Citric acid, potassium citrate, and sodium citrate may also be used for other purposes not listed in this medication guide.

What are the possible side effects of citric acid, potassium citrate, and sodium citrate (Cytra-3, Polycitra, Polycitra-LC, Tricitrates)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • swelling, rapid weight gain;
  • numbness or tingly feeling in your hands or feet, or around your mouth;
  • muscle twitching or pain, leg pain or cramps;
  • fast, slow, or uneven heart rate;
  • unusual weakness, rapid and shallow breathing, dizziness, confusion, or mood changes;
  • feeling restless, nervous, or irritable;
  • black, bloody, or tarry stools;
  • coughing up blood or vomit that looks like coffee grounds;
  • severe stomach pain, ongoing diarrhea or vomiting; or
  • seizure (convulsions).

Less serious side effects may include:

  • nausea, or vomiting, stomach pain;
  • mild or occasional diarrhea; or
  • mild stomach pain.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about citric acid, potassium citrate, and sodium citrate (Cytra-3, Polycitra, Polycitra-LC, Tricitrates)?

You should not use this medication if you have severe kidney disease, severe heart damage (such as from a prior heart attack), Addison's disease (an adrenal gland disorder), high levels of potassium or sodium in your blood, or if you are severely dehydrated.

You should not take citric acid, potassium citrate, and sodium citrate tablets if you have problems with your esophagus, stomach, or intestines that make it difficult for you to swallow or digest pills.

Before you take citric acid, potassium citrate, and sodium citrate, tell your doctor about all your medical conditions, especially kidney disease, heart disease, high blood pressure, a history of heart attack, urinary problems, diabetes, swelling (edema), urination problems, stomach ulcer or chronic diarrhea (such as ulcerative colitis, Crohn's disease), or if you are on a low-salt diet.

Also tell your doctor about all other medications you use, including antacids, heart or blood pressure medications, or a diuretic (water pill).

To be sure this medication is helping your condition, your blood and urine may need to be tested often. Your heart rate may also be checked using an electrocardiograph or ECG (sometimes called an EKG) to measure electrical activity of the heart. Follow your doctor's instructions carefully and do not miss any scheduled appointments.

Serious side effects of citric acid, potassium citrate, and sodium citrate include numbness or tingly feeling, swelling or rapid weight gain, muscle twitching or cramps, fast or slow heart rate, confusion, or mood changes, bloody or tarry stools, severe stomach pain, ongoing diarrhea, or seizure (convulsions).



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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