Medications and Drugs

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Brand Names: Onfi

Generic Name: clobazam (Pronunciation: KLOE ba zam)

• What is clobazam (Onfi)?
• What are the possible side effects of clobazam (Onfi)?
• What is the most important information I should know about clobazam (Onfi)?
• What should I discuss with my healthcare provider before taking clobazam (Onfi)?
• How should I take clobazam (Onfi)?
• What happens if I miss a dose (Onfi)?
• What happens if I overdose (Onfi)?
• What should I avoid while taking clobazam (Onfi)?
• What other drugs will affect clobazam (Onfi)?
• Where can I get more information?

What is clobazam (Onfi)?

Clobazam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen). Clobazam affects chemicals in the brain that may become unbalanced and cause anxiety.

Clobazam is used in combination with other medications to treat seizures caused by Lennox-Gastaut syndrome, a severe form of childhood epilepsy that also causes developmental and behavior problems.

Clobazam may also be used for purposes not listed in this medication guide.

What are the possible side effects of clobazam (Onfi)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself.

Stop using clobazam and call your doctor at once if you have a serious side effect such as:

• confusion, hallucinations;
• fever, chills, cough with yellow or green mucus, feeling short of breath;
• feeling like you might pass out;
• pain or burning when you urinate;
• urinating less than usual or not at all; or
• severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

• drowsiness, dizziness;
• feeling weak, tired, or irritable;
• slurred speech, loss of balance or coordination;
• appetite changes;
• drooling;
• sleep problems (insomnia);
• constipation, vomiting, trouble swallowing;
• mild fever;
• dry cough.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about clobazam (Onfi)?

You should not use clobazam if you are allergic to it.

Before taking clobazam, tell your doctor if you have kidney or liver disease, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol.

You may have thoughts about suicide while taking this medication. Your doctor will need to check you at regular visits.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), depressed, or have thoughts about suicide or hurting yourself.

This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Do not drink alcohol while taking clobazam.

Clobazam may be habit-forming and should be used only by the person it was prescribed for. Keep the medication in a secure place where others cannot get to it.

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