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Brand Names: Anafranil

Generic Name: clomipramine (Pronunciation: kloe MI pra meen)

• What is clomipramine (Anafranil)?
• What are the possible side effects of clomipramine (Anafranil)?
• What is the most important information I should know about clomipramine (Anafranil)?
• What should I discuss with my healthcare provider before taking clomipramine (Anafranil)?
• How should I take clomipramine (Anafranil)?
• What happens if I miss a dose (Anafranil)?
• What happens if I overdose (Anafranil)?
• What should I avoid while taking clomipramine (Anafranil)?
• What other drugs will affect clomipramine (Anafranil)?
• Where can I get more information?

What is clomipramine (Anafranil)?

Clomipramine is a tricyclic antidepressant. It affects chemicals in the brain that may become unbalanced.

Clomipramine is used to treat symptoms of obsessive-compulsive disorder (OCD) such as recurrent thoughts or feelings and repetitive actions.

Clomipramine may also be used for purposes other than those listed in this medication guide.

Clomipramine 25 mg-MYL

orange/peach, imprinted with MYLAN 3025

Clomipramine 25 mg-TEV

orange/white, imprinted with 93 956

Clomipramine 50 mg-GG

white, imprinted with GG 823

Clomipramine 50 mg-MYL

peach/yellow, imprinted with MYLAN 3050

Clomipramine 50 mg-TEV

blue/white, imprinted with 93 958

Clomipramine 50 mg-WAT

yellow, imprinted with WATSON595, 50MG

Clomipramine 75 mg-MYL

orange/peach, imprinted with MYLAN 3075

Clomipramine 75 mg-TEV

brown/white, imprinted with 93 960

What are the possible side effects of clomipramine (Anafranil)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

• chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;
• sudden numbness or weakness, especially on one side of the body;
• sudden headache, confusion, problems with vision, speech, or balance;
• feeling light-headed, fainting;
• fever, confusion, muscle stiffness, sweating, fast or uneven heartbeats;
• pale skin, easy bruising or bleeding, unusual weakness; or
• urinating more than usual.

Less serious side effects may be more likely to occur, such as:

• nausea, vomiting, stomach pain, loss of appetite, constipation or diarrhea;
• dry mouth, unpleasant taste;
• increased appetite, weight changes;
• feeling anxious, restless, dizzy, drowsy, or tired;
• blurred vision, trouble concentrating;
• sleep problems (insomnia), nightmares;
• blurred vision;
• increased sweating; or
• decreased sex drive, impotence, or difficulty having an orgasm.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about clomipramine (Anafranil)?

Do not use this medication if you have recently had a heart attack, or if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days.

Do not use clomipramine if you are allergic to it or to similar drugs such as amitriptyline (Elavil, Etrafon), amoxapine (Ascendin), desipramine (Norpramin), doxepin (Sinequan), imipramine (Janimine, Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil).

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

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