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What should I discuss with my healthcare provider before taking clomipramine (Anafranil)?
You should not take this medication if you are allergic to clomipramine or to similar antidepressants such as amitriptyline, amoxapine, desipramine, doxepin, imipramine, nortriptyline, protriptyline, or trimipramine.
Do not use clomipramine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
To make sure clomipramine is safe for you, tell your doctor if you have any of these conditions:
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using clomipramine. Your family or other caregivers should also be alert to changes in your mood or symptoms.
FDA pregnancy category C. It is not known whether clomipramine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
Clomipramine can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using this medication.
Do not give clomipramine to anyone younger than 18 years old without the advice of a doctor.
How should I take clomipramine (Anafranil)?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take clomipramine with food to reduce stomach upset.
It may take up to 4 weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 4 weeks of treatment.
If you need surgery, tell the surgeon ahead of time that you are using clomipramine. You may need to stop using the medicine for a short time.
Do not stop using clomipramine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using clomipramine.
Store at room temperature away from moisture and heat.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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