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What should I discuss with my healthcare provider before taking clorazepate (Tranxene SD, Tranxene T-Tab)?

Do not use this medication if you have narrow-angle glaucoma, or if you are allergic to clorazepate or to other benzodiazepines, such as alprazolam (Xanax), chlordiazepoxide (Librium), diazepam (Valium), lorazepam (Ativan), or oxazepam (Serax).

Before taking clorazepate, tell your doctor if you are allergic to any drugs, or if you have:

• glaucoma;
• asthma, emphysema, bronchitis, chronic obstructive pulmonary disorder (COPD), or other breathing problems;
• kidney or liver disease;
• epilepsy or other seizure disorder;
• a history of depression or suicidal thoughts or behavior; or
• a history of drug or alcohol addiction.

If you have any of these conditions, you may need a dose adjustment or special tests during treatment.

Clorazepate can pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

The sedative effects of clorazepate may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking clorazepate.

Do not give this medication to a child younger than 9 years old.

How should I take clorazepate (Tranxene SD, Tranxene T-Tab)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Clorazepate should be used for only a short time. Do not take this medication for longer than 4 months without your doctor's advice.

Clorazepate may be habit-forming and should be used only by the person it was prescribed for. Clorazepate should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.

Contact your doctor if this medicine seems to stop working as well in treating your anxiety symptoms.

Do not stop using clorazepate suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

Your symptoms may return when you stop using clorazepate after using it over a long period of time. You may also have withdrawal symptoms when you stop using clorazepate. Withdrawal symptoms may include tremor, sweating, trouble sleeping, muscle cramps, stomach pain, vomiting, diarrhea, irritability, memory problems, confusion, unusual thoughts or behavior, and seizure (convulsions).

To be sure this medication is not causing harmful effects, your blood and liver function may need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

Store clorazepate at room temperature away from moisture, heat, and light.

Keep track of how many pills have been used from each new bottle of this medicine. Benzodiazepines are drugs of abuse and you should be aware if any person in the household is using this medicine improperly or without a prescription.

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