What happens if I miss a dose (Colcrys)?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Colcrys)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of colchicine can be fatal.
Overdose symptoms may include diarrhea (may be bloody and severe), nausea, vomiting, stomach pain, heartburn, a burning feeling in your throat or stomach, muscle weakness, urinating less than usual, numbness or tingling, fainting, or seizure (convulsions).
What should I avoid while taking colchicine (Colcrys)?
Grapefruit and grapefruit juice may interact with colchicine and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
What other drugs will affect colchicine (Colcrys)?
Colchicine can interact with certain other drugs. A colchicine drug interaction can be fatal. Tell your doctor about all other medications you use, especially:
- conivaptan (Vaprisol);
- digoxin (Lanoxin, digitalis);
- imatinib (Gleevec);
- isoniazid (for treating tuberculosis);
- an antidepressant such as nefazodone;
- an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), or telithromycin (Ketek);
- antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);
- cholesterol-lowering medicines such as atorvastatin (Lipitor), fenofibrate (Antara, Lipofen, TriCor), fluvastatin (Lescol), gemfibrozil (Lopid), lovastatin (Mevacor, Altoprev, Advicor), pravastatin (Pravachol), simvastatin (Zocor, Simcor, Vytorin), and others;
- heart or blood pressure medication such as amiodarone (Cordarone, Pacerone), diltiazem (Cartia, Cardizem), felodipine (Plendil), nicardipine (Cardene), nifedipine (Nifedical, Procardia), quinidine (Quin-G), reserpine, verapamil (Calan, Covera, Isoptin, Verelan), and others;
- HIV or AIDS medication such as atazanavir (Reyataz), darunavir (Prezista), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), ritonavir (Kaletra, Norvir), tipranavir (Aptivus); or
- medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf).
This list is not complete and there may be other drugs that can interact with colchicine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about colchicine.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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