Medications and Drugs
Brand Names: Xiaflex
Generic Name: collagenase clostridium histolyticum (Pronunciation: KOL a JEN ase klos TRID ee um HIS toe LIT ik um)
What is collagenase clostridium histolyticum (Xiaflex)?
Collagenase clostridium histolyticum is made from a mixture of proteins derived from a certain bacteria.
Collagenase clostridium histolyticum is used to treat Dupuytren's contracture in adults. This condition causes an abnormal thickening of the tissue in the palm of the hand. This condition may get worse over time and form a "cord" in your palm, causing a permanent bend in your finger.
Collagenase clostridium histolyticum may also be used for purposes not listed in this medication guide.
What are the possible side effects of collagenase clostridium histolyticum (Xiaflex)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Tell your caregiver at once if you have a serious side effect such as:
Less serious side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about collagenase clostridium histolyticum (Xiaflex)?
Before you receive this medication, tell your doctor if you have a bleeding or blood clotting disorder, such as hemophilia.
The day after your injection, your doctor will need to examine your hand to see if your condition has improved. Avoid any strenuous activity using the treated hand until your doctor tells you to resume normal activities.
Tell your caregiver at once if you have a serious side effect in the treated hand, such as bruising, bleeding, swelling, redness, warmth, numbness, tingling, or sudden pain or loss of movement.
Call your doctor if you have fever, chills, body aches, flu symptoms, or swollen glands in your elbow or underarm.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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