What happens if I miss a dose (Xiaflex)?

Call your doctor for instructions if you miss an appointment for your collagenase clostridium histolyticum injection.

What happens if I overdose (Xiaflex)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

Overdose symptoms may include some of the serious side effects listed in this medication guide.

What should I avoid before and after receiving collagenase clostridium histolyticum (Xiaflex)?

Until you visit your doctor the day after your injection, do not flex or extend the fingers of your treated hand. Doing so may cause the medicine to spread away from the treatment area, making it less effective.

Avoid any strenuous activity using the treated hand until your doctor tells you to resume normal activities.

What other drugs can affect collagenase clostridium histolyticum (Xiaflex)?

Before you receive this medication, tell your doctor about all other medicines you have used within the past 7 days, especially medication used to prevent blood clots, such as:

• high doses of aspirin (more than 150 milligrams per day);
• a blood thinner such as warfarin (Coumadin);
• argatroban (Acova), bivalirudin (Angiomax), lepirudin (Refludan);
• dalteparin (Fragmin), enoxaparin (Lovenox), fondaparinux (Arixtra); or
• abciximab (ReoPro), anagrelide (Agrylin), cilostazol (Pletal), clopidogrel (Plavix), dipyridamole (Persantine, Aggrenox), eptifibatide (Integrelin), prasugrel (Effient), ticlopidine (Ticlid), tirofiban (Aggrastat).

This list is not complete and other drugs may interact with collagenase clostridium histolyticum. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

Your doctor or pharmacist can provide more information about collagenase clostridium histolyticum.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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