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What should I discuss with my health care provider before using collagenase topical (Santyl)?

You should not use collagenase topical if you are allergic to it.

To make sure you can safely use this medication, tell your doctor about all of your medical conditions.

It is not known whether collagenase topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether collagenase topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use collagenase topical (Santyl)?

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Apply this medication only to the affected skin wound. Try not to get any ointment on the healthy skin around the wound.

Collagenase topical is usually applied once daily. You may need to apply it more often if the wound area becomes soiled.

You may apply collagenase topical directly to the wound, or apply it to a sterile gauze pad and then to the wound.

Before applying collagenase topical, rinse the skin area several times with normal saline solution or other cleanser recommended by your doctor. Collagenase topical may be less effective if you apply it to skin that has been treated with certain cleansers or antiseptic solutions.

Remove as much of the loose tissue as possible before applying the medication. Soak a gauze pad with the cleansing solution recommended by your doctor. Gently rub the wound to remove the loose skin and debris.

Your doctor may recommend using an antibiotic powder on the affected skin before you apply collagenase topical. Follow your doctor's instructions about the type and amount of antibiotic powder to use.

The enzymes in collagenase topical may increase your risk of a bacterial infection in your blood stream. Call your doctor right away if you have any signs of infection such as fever, chills, rapid heartbeats, nausea, vomiting, stomach pain, or feeling very ill.

Store at room temperature away from moisture and heat.

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