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What should I discuss with my health care provider before receiving conivaptan (Vaprisol)?

You should not receive this medication if you are allergic to conivaptan or corn products, or if you are unable to urinate.

You should not use conivaptan if you are using any of the following drugs:

• imatinib (Gleevec);
• isoniazid (for treating tuberculosis);
• an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), or telithromycin (Ketek);
• an antidepressant such as nefazodone;
• antifungal medication such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), or voriconazole (Vfend);
• heart or blood pressure medication such as diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others; or
• HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir, Kaletra).

To make sure you can safely receive conivaptan, tell your doctor if you have any of these other conditions:

• congestive heart failure;
• liver disease;
• kidney disease;
• alcoholism; or
• if you are malnourished.

FDA pregnancy category C. It is not known whether conivaptan will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether conivaptan passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are receiving conivaptan.

How is conivaptan given (Vaprisol)?

Conivaptan is injected into a vein through an IV. You will receive this injection in a hospital setting. Conivaptan is given through an IV line and a needle placed into one of your large veins (such as in your upper chest).

Conivaptan is infused around-the-clock for up to 4 days. This medication is usually given only in a hospital.

Because conivaptan can irritate the skin or vein when the medicine enters the body, your IV needle will be moved to a different vein every 24 hours.

To be sure this medicine is helping your condition, your blood will need to be tested often.

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