Medications and Drugs

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Brand Names: Danocrine

Generic Name: danazol (Pronunciation: DAN a zol)

• What is danazol (Danocrine)?
• What are the possible side effects of danazol (Danocrine)?
• What is the most important information I should know about danazol (Danocrine)?
• What should I discuss with my healthcare provider before taking danazol (Danocrine)?
• How should I take danazol (Danocrine)?
• What happens if I miss a dose (Danocrine)?
• What happens if I overdose (Danocrine)?
• What should I avoid while taking danazol (Danocrine)?
• What other drugs will affect danazol (Danocrine)?
• Where can I get more information?

What is danazol (Danocrine)?

Danazol is a man-made form of a steroid. Danazol affects the ovaries and pituitary gland and prevents the release of certain hormones in the body.

Danazol is used to treat endometriosis and fibrocystic breast disease. Danazol is also used to prevent attacks of angioedema in people with an inherited form of this disorder.

Danazol may also be used for other purposes not listed in this medication guide.

Danazol 100 mg-BAR

yellow, imprinted with barr, 634

Danazol 200 mg-BAR

orange/yellow, imprinted with barr, 635

Danazol 50 mg-BAR

white/yellow, imprinted with barr, 633

What are the possible side effects of danazol (Danocrine)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

• sudden numbness or weakness, confusion, problems with vision, speech, or balance;
• chest pain, sudden cough, wheezing, rapid breathing, fast heart rate;
• swelling, rapid weight gain, feeling short of breath;
• headache, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes; or
• stomach pain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

• acne or other skin problems;
• increased hair growth or hair loss;
• weight gain;
• breast changes;
• deepened voice;
• nervousness;
• increased sweating, warmth or tingly feeling under your skin;
• changes in your menstrual periods; or
• vaginal dryness, discomfort, or itching.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about danazol (Danocrine)?

You should not use this medication if you are allergic to danazol, or if you have porphyria, or severe problems with your heart, liver, or kidney. You also should not take danazol if you are pregnant or breast-feeding, or if you have abnormal vaginal bleeding that has not been checked by a doctor.

This medication can cause birth defects. Do not use if you are pregnant.

Before you start taking danazol, you may need to have a pregnancy test to make sure you are not pregnant.

Use an effective barrier form of birth control (such as a condom or diaphragm with spermicide gel or inserts). Hormonal forms of contraception (such as birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during your treatment.

Your medication needs may change if you have unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you.

Call your doctor at once if you have a serious side effect such as sudden numbness or weakness, problems with vision or speech, chest pain, sudden cough, or wheezing, swelling, rapid weight gain, feeling short of breath, ringing in your ears, dizziness, nausea, pain behind your eyes, stomach pain and loss of appetite, dark urine, or jaundice (yellowing of the skin or eyes).

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