What happens if I miss a dose (Prezista)?
Take the missed dose of darunavir and ritonavir as soon as you remember and take your next dose at the regularly scheduled time.
If you take darunavir 800 milligrams once daily and you are more than 12 hours late in taking your medications, skip the missed dose and take the next regularly scheduled dose. Do not take extra medicine to make up the missed dose.
If you take darunavir 600 milligrams twice daily and you are more than 6 hours late in taking your medications, skip the missed dose and take the next regularly scheduled dose.
Always take darunavir and ritonavir together. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Prezista)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking darunavir (Prezista)?
If you also take didanosine, take it 1 hour before or 2 hours after you take darunavir.
Taking this medication will not prevent you from passing HIV to other people. Avoid having unprotected sex or sharing razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
What other drugs will affect darunavir (Prezista)?
Many drugs can interact with darunavir. Below is just a partial list. Tell your doctor if you are using:
- bosentan (Tracleer);
- buprenorphine and naloxone (Suboxone);
- colchicine (Colcrys);
- methadone (Methadose, Dolophine, Diskets);
- risperidone (Risperdal) or thioridazine (Mellaril);
- salmeterol (Serevent);
- an antibiotic such as clarithromycin (Biaxin), rifabutin (Mycobutin);
- an antidepressant such as desipramine (Norpramin), trazodone (Desyrel), and others;
- an antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);
- beta-blockers such as metoprolol (Lopressor, Toprol) or timolol (Blocadren, Betimol, Cosopt, Timoptic);
- a blood thinner such as warfarin (Coumadin);
- cholesterol-lowering medicine such as atorvastatin (Lipitor) pravastatin (Pravachol), rosuvastatin (Crestor);
- heart or blood pressure medicine such as felodipine (Plendil), nicardipine (Cardene), nifedipine (Nifedical, Procardia), and others;
- medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf);
- a heart rhythm medication such as amiodarone (Cordarone), digoxin (digitalis, Lanoxin), flecainide (Tambocor), lidocaine, propafenone (Rythmol), or quinidine (Quin-G);
- insulin or diabetes medication you take by mouth;
- medicines to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);
- other HIV /AIDS medicine such as efavirenz (Sustiva), lopinavir/ritonavir (Kaletra), or saquinavir (Invirase, Fortovase);
- seizure medications such as carbamazepine (Carbatrol, Tegretol), phenobarbital (Luminal, Solfoton), or phenytoin (Dilantin); or
- a steroid medication such as dexamethasone (Decadron, Hexadrol) or fluticasone (Advair, Flonase, Flovent).
This list is not complete and other drugs may interact with darunavir. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about darunavir.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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