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What should I discuss with my health care provider before using denileukin diftitox (Ontak)?

You should not use denileukin diftitox if you have ever had an allergic reaction to a diphtheria vaccine or to medicines containing interleukin-2 (IL-2).

If you have heart disease, you may need a dose adjustment or special tests.

FDA pregnancy category C. It is not known whether denileukin diftitox will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether denileukin diftitox passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Some patients receiving denileukin diftitox have had permanent changes in their vision or ability to see colors. Talk with your doctor about your individual risk. Tell your doctor if you have any vision changes during your treatment.

How should I use denileukin diftitox (Ontak)?

Denileukin diftitox is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. This medication must be given slowly, and the IV infusion can take at least 15 minutes to complete. During this time you will be observed for side effects.

Denileukin diftitox is usually given each day for 5 days, followed by 3 weeks off the medication.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis before and during your treatment. Visit your doctor regularly.

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