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What should I discuss with my healthcare provider before taking desipramine (Norpramin)?
You should not take this medication if you have recently had a heart attack, or if you are allergic to desipramine or to similar antidepressants such as amitriptyline, amoxapine, clomipramine, doxepin, imipramine, nortriptyline, protriptyline, or trimipramine.
Do not use desipramine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.
To make sure desipramine is safe for you, tell your doctor if you have:
Some young people have thoughts about suicide when first taking an antidepressant. Your doctor will need to check your progress at regular visits while you are using desipramine. Your family or other caregivers should also be alert to changes in your mood or symptoms.
It is not known whether desipramine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
It is not known whether desipramine passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Serious side effects may be more likely in older adults and those who are ill or debilitated.
Do not give this medicine to a child without medical advice.
How should I take desipramine (Norpramin)?
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.
If you need surgery, tell the surgeon ahead of time that you are using desipramine. You may need to stop using the medicine for a short time.
Do not stop using desipramine suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using desipramine.
It may take up to a few weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve during treatment.
Store at room temperature away from moisture and heat.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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