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What should I discuss with my healthcare provider before taking oral desmopressin (DDAVP)?

You should not take this medication if you are allergic to desmopressin, or if you have:

• severe kidney disease; or
• if you have ever had hyponatremia (low sodium levels in your body).

Before taking desmopressin, tell your doctor if you are allergic to any medications, or if you have:

• heart disease, coronary artery disease;
• congestive heart failure;
• kidney disease;
• cystic fibrosis;
• high or low blood pressure;
• an electrolyte imbalance; or
• a psychologic disorder that causes extreme or unusual thirst.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take desmopressin.

FDA pregnancy category B. This medication is not expected to harm an unborn baby. Do not use desmopressin without telling your doctor if you are pregnant.

It is not known whether desmopressin passes into breast milk, or if it could harm a nursing baby. Do not use desmopressin without telling your doctor if you are breast-feeding a baby.

How should I take desmopressin (DDAVP)?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

It is very important to reduce your intake of water and other fluids while you are taking desmopressin. Drinking too much water can cause your body to lose sodium, which may lead to a serious, life-threatening electrolyte imbalance.

Fluid restriction is especially important in children and older adults taking desmopressin. Follow your doctor's instructions about the type and amount of liquids you should drink.

If you are switching from desmopressin nasal spray to desmopressin tablets, wait at least 24 hours after your last nasal dose before you take your first tablet.

To be sure this medication is helping your condition, your blood will need to be tested often. This will help your doctor determine how long to treat you with desmopressin. Do not miss any scheduled appointments.

Store the tablets at room temperature away from moisture, light, and heat.

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