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Medications and Drugs

Brand Names: Cytuss-HC NR, H-C Tussive-NR, Histussin HC

Generic Name: dexbrompheniramine, hydrocodone, and phenylephrine (Pronunciation: DEX brom fen IR a meen, HYE dro KOE done, FEN il EFF rin)

What is dexbrompheniramine, hydrocodone, and phenylephrine (Cytuss-HC NR, H-C Tussive-NR, Histussin HC)?

Brompheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Hydrocodone is a narcotic cough suppressant.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of dexbrompheniramine, hydrocodone, and phenylephrine is used to treat nasal congestion, sneezing, runny nose, itchy or water eyes, and cough caused by allergies or the common cold.

Dexbrompheniramine, hydrocodone, and phenylephrine may also be used for other purposes not listed in this medication guide.

What are the possible side effects of dexbrompheniramine, hydrocodone, and phenylephrine (Cytuss-HC NR, H-C Tussive-NR, Histussin HC)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • shallow breathing, slow heartbeat;
  • fast or pounding heartbeat;
  • slow heart rate, weak pulse, fainting, slow breathing (breathing may stop);
  • confusion, hallucinations, unusual thoughts or behavior;
  • seizure (convulsions);
  • painful or difficult urination;
  • urinating less than usual or not at all; or
  • severe dizziness, anxiety, fear, or tremors.

Less serious side effects may include:

  • dizziness, drowsiness, headache;
  • feeling restless or nervous;
  • sleep problems (insomnia);
  • nausea, vomiting, heartburn, loss of appetite;
  • dry mouth;
  • increased urination; or
  • blurred vision.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about dexbrompheniramine, hydrocodone, and phenylephrine (Cytuss-HC NR, H-C Tussive-NR, Histussin HC)?

Do not use this medication if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take a cough and cold medicine before the MAO inhibitor has cleared from your body.

You should not use dexbrompheniramine, hydrocodone, and phenylephrine if you are allergic to it, or if you have severe or uncontrolled high blood pressure, coronary artery disease, ischemic heart disease (reduced circulation of blood to the heart), narrow-angle glaucoma, peptic ulcer, if you are unable to urinate, or if you are pregnant or breast-feeding.

Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. This medication should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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