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Medications and Drugs

Brand Names: Durahist D, Histatab D

Generic Name: dexchlorpheniramine, methscopolamine, and pseudoephedrine (Pronunciation: DEX klor fen EER a meen, METH sko POE la meen, SOO doe ee FED rin)

What is dexchlorpheniramine, methscopolamine, and pseudoephedrine (Durahist D, Histatab D)?

Dexchlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Methscopolamine reduces secretion of fluids in the body that cause sneezing, runny nose, and postnasal drip.

Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of dexchlorpheniramine, methscopolamine, and pseudoephedrine is used to treat runny or stuffy nose, sneezing, watery eyes, and sinus congestion caused by allergies, the common cold, or the flu.

Dexchlorpheniramine, methscopolamine, and pseudoephedrine may also be used for purposes not listed in this medication guide.

What are the possible side effects of dexchlorpheniramine, methscopolamine, and pseudoephedrine (Durahist D, Histatab D)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects:

  • fast or irregular heart rate;
  • feeling like you might pass out;
  • rash or flushing; or
  • eye pain.

Less serious side effects may include:

  • dryness of your eyes, nose, and mouth;
  • blurred vision;
  • headache, dizziness;
  • weakness or nervousness;
  • nausea, bloating, heartburn, or constipation;
  • changes in taste;
  • difficulty urinating;
  • decreased sweating; or
  • feeling restless or excited (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about dexchlorpheniramine, methscopolamine, and pseudoephedrine (Durahist D, Histatab D)?

Do not take dexchlorpheniramine, methscopolamine, and pseudoephedrine if you have used a monoamine oxidase inhibitor (MAOI) such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Drinking alcohol can increase certain side effects of dexchlorpheniramine, methschopolamine, and pseudoephedrine.

Before using this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by methscopolamine.

Ask a doctor or pharmacist before using any other cold or allergy medicine. Antihistamines and decongestants are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain drug. Check the label to see if a medicine contains an antihistamine or decongestant.

Avoid taking diet pills, caffeine pills, or other stimulants (such as ADHD medications) without your doctor's advice. Taking a stimulant together with a decongestant can increase your risk of unpleasant side effects.

Do not take dexchlorpheniramine, methscopolamine, and pseudoephedrine for longer than 7 days in a row. If your symptoms do not improve, or if they get worse and you also have a fever, talk to your doctor.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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