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What should I discuss with my health care provider before receiving dexrazoxane (Totect, Zinecard)?

You should not receive Zinecard if your chemotherapy does not include doxorubicin or a similar medication such as:

• daunorubicin (Cerubidine);
• epirubicin (Ellence);
• idarubicin (Idamycin); or
• mitoxantrone (Novantrone);

If possible before you receive dexrazoxane, tell your doctor if you have:

• liver disease;
• kidney disease; or
• if you are pregnant or breast-feeding.

It is not known whether dexrazoxane passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are using dexrazoxane.

In an emergency situation, it may not be possible before you are treated with Totect to tell your caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medication.

How is dexrazoxane given (Totect, Zinecard)?

Dexrazoxane is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.

Totect is usually started within 6 hours after extravasation, and continued once daily for 3 days.

Zinecard is usually started 30 minutes before you receive your doxorubicin injection.

Dexrazoxane can add to the bone marrow lowering effects of chemotherapy. This can weaken your immune system, making it easier for you to get sick from being around others who are ill.

To be sure this medication is not causing harmful effects, your blood cells and kidney function will need to be tested often. Do not miss any follow up visits to your doctor for blood or urine tests.

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