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Medications and Drugs

Brand Names: Certuss-D, Duraphen Forte, Duraphen II DM, Sinutuss DM

Generic Name: dextromethorphan, guaifenesin, and phenylephrine (Pronunciation: dex troe meth OR fan, gwye FEN e sin, fen il EFF rin)

What is dextromethorphan, guaifenesin, and phenylephrine (Certuss-D, Duraphen Forte, Duraphen II DM, Sinutuss DM)?

Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex.

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

The combination of dextromethorphan, guaifenesin, and phenylephrine is used to treat stuffy nose, sinus congestion, cough, and chest congestion caused by the common cold or flu.

Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.

Dextromethorphan, guaifenesin, and phenylephrine may also be used for other purposes not listed in this medication guide.

Duraphen II DM

oblong, white, imprinted with PE 715

What are the possible side effects of dextromethorphan, guaifenesin, and phenylephrine (Certuss-D, Duraphen Forte, Duraphen II DM, Sinutuss DM)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • severe dizziness, anxiety, restless feeling, or nervousness;
  • confusion, hallucinations; or
  • slow, shallow breathing.

Less serious side effects may include:

  • dizziness or headache,
  • a rash, or
  • nausea, vomiting, or stomach upset.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about dextromethorphan, guaifenesin, and phenylephrine (Certuss-D, Duraphen Forte, Duraphen II DM, Sinutuss DM)?

Do not give this medication to a child younger than 2 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Do not use a cough or cold medicine if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take cough or cold medicine before the MAO inhibitor has cleared from your body.

Do not use any other over-the-counter cough, cold, allergy, or sleep medication without first asking your doctor or pharmacist. If you take certain products together you may accidentally take too much of one or more types of medicine. Read the label of any other medicine you are using to see if it contains a decongestant, expectorant, or cough suppressant.

Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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