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What should I discuss with my healthcare provider before I receive difluprednate ophthalmic (Durezol)?

You should not use this medication if you are allergic to difluprednate, or if you have any type of infection, especially:

• a fungal or bacterial eye infection;
• any type of viral eye infection, such as ocular herpes; or
• an untreated infection in your eye or elsewhere, including chickenpox.

Before using difluprednate ophthalmic, tell your doctor if you are allergic to any drugs, or if you have herpes. You may need a dose adjustment or special tests to safely use difluprednate.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether difluprednate ophthalmic passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use difluprednate ophthalmic (Durezol)?

Use this medication exactly as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Difluprednate ophthalmic is usually given 4 times per day beginning 24 hours after your surgery and continuing for 2 weeks. After the first 2 weeks, your dose may be decreased to 2 times per day for 1 week or longer. Follow your doctor's instructions.

Wash your hands before using the eye drops.

To apply the eye drops:

• Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the dropper tip down. Look up and away from the dropper as you squeeze out a drop, then close your eye.
• Gently press your finger to the inside corner of the eye (near your nose) for about 1 minute to keep the liquid from draining into your tear duct.
• Use the eye drops only in the eye you are having surgery on.
• Do not allow the dropper tip to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

Tell your doctor if your symptoms do not improve after 2 days of treatment with difluprednate ophthalmic.

Do not stop using difluprednate suddenly without first talking to your doctor. You may need to use less and less before you stop the medication completely.

To be sure this medication is not causing harmful effects, your eyes may need to be checked on a regular basis. Do not miss any scheduled visits to your doctor.

Store this medication at room temperature away from heat, moisture, and light. Do not freeze. Keep the bottle tightly closed when not in use.

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