dihydroergotamine (injection) (cont.)
What happens if I miss a dose (D.H.E. 45)?
Since dihydroergotamine is used on an as-needed basis, you are not likely to miss a dose. Do not use more than 3 injections of dihydroergotamine per day or more than 6 injections per week.
What happens if I overdose (D.H.E. 45)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of dihydroergotamine can be fatal. Overdose symptoms may include some of the serious side effects listed in this medication guide.
What should I avoid while using dihydroergotamine injection (D.H.E. 45)?
Do not use dihydroergotamine injection within 24 hours before or after using another migraine headache medicine, including:
- another ergot medicine such as ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (Migranal), or methylergonovine (Methergine); or
- almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), sumatriptan (Imitrex), rizatriptan (Maxalt, Maxalt-MLT), or zolmitriptan (Zomig).
Grapefruit and grapefruit juice may interact with dihydroergotamine injection and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
What other drugs will affect dihydroergotamine injection (D.H.E. 45)?
Many drugs can interact with dihydroergotamine. Below is just a partial list. Tell your doctor if you are using:
- zileuton (Zyflo);
- nicotine (Nicoderm, Nicorette);
- cold or allergy medications, diet pills, stimulants, or medication to treat ADHD (such as Ritalin or Adderall);
- an antidepressant such fluoxetine (Prozac), sertraline (Zoloft), and others;
- fluconazole (Diflucan) or other antifungal medication; or
- heart or blood pressure medication such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), propranolol (Inderal, InnoPran), and others.
This list is not complete and other drugs may interact with dihydroergotamine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your pharmacist can provide more information about dihydroergotamine injection.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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