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Medications and Drugs

Brand Names: Analpram Advanced

Generic Name: diosmiplex, hydrocortisone, and pramoxine (Pronunciation: dye OS me plex, HYE droe KORT i sone, and pra MOX een)

What is diosmiplex, hydrocortisone, and pramoxine (Analpram Advanced)?

Diosmiplex (Vasculera) is a medical food for people with chronic venous insufficiency, a blood circulation disorder. Diosmiplex affects the function of blood vessels in the body.

Pramoxine is an anesthetic. It works by interfering with pain signals sent from the nerves to the brain.

Hydrocortisone is a steroid. It reduces the actions of chemicals in the body that cause inflammation, redness, and swelling.

Diosmiplex is a oral tablet you take by mouth. Diosmiplex, hydrocortisone, and pramoxine are combined into a cream to be applied to the rectum. The two forms of medicine are supplied in a kit that also contains cleansing wipes.

The diosmiplex, hydrocortisone, and pramoxine kit is used to treat itching, swelling, or irritation caused by hemorrhoids.

Diosmiplex, hydrocortisone, and pramoxine may also be used for purposes not listed in this medication guide.

What are the possible side effects of diosmiplex, hydrocortisone, and pramoxine (Analpram Advanced)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • severe burning, itching or irritation of the treated area; or
  • rectal bleeding.

Less serious side effects may include:

  • mild burning, itching, or dryness of the treated area.
  • headache;
  • mild skin rash;
  • leg cramps;
  • upset stomach; or
  • swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about diosmiplex, hydrocortisone, and pramoxine (Analpram Advanced)?

You should not use this medication if you are allergic to diosmiplex, hydrocortisone, or pramoxine.

Before using diosmiplex, hydrocortisone, and pramoxine , tell your doctor if you have liver or kidney disease, diabetes, or a history of cancer.

Do not use this medication on a child without a doctor's advice. Children are more sensitive to the effects of topical hydrocortisone.

Do not cover the treated rectal areas with a bandage or other covering unless your doctor has told you to. If you are treating the diaper area of a baby, do not use plastic pants or tight-fitting diapers. Covering the area that is treated with hydrocortisone topical can increase the amount of the drug your skin absorbs, which may lead to unwanted side effects. Follow your doctor's instructions.

Contact your doctor if your condition does not improve or if it gets worse after using this medication.

Do not use diosmiplex, hydrocortisone, and pramoxine to treat any condition that has not been checked by your doctor.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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