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Medications and Drugs

Brand Names: Endal HD, Tussinate

Generic Name: diphenhydramine, hydrocodone, and phenylephrine (Pronunciation: dye fen HYE dra meen, hye droe KOE dohn, feh nill EH frin)

What is diphenhydramine, hydrocodone, and phenylephrine (Endal HD, Tussinate)?

Diphenhydramine is an antihistamine. It blocks the effects of the naturally occurring chemical histamine in the body and reduces congestion.

Hydrocodone is a narcotic. It is a pain reliever and a cough suppressant.

Phenylephrine is a decongestant. It works by constricting (shrinking) blood vessels (veins and arteries) in the body. Constriction of blood vessels in the sinuses and nose decreases congestion.

Diphenhydramine, hydrocodone, and phenylephrine is used to treat cough and nasal congestion associated with upper respiratory tract infections and allergies.

Diphenhydramine, hydrocodone, and phenylephrine may also be used for purposes other than those listed in this medication guide.

What are the possible side effects of diphenhydramine, hydrocodone, and phenylephrine (Endal HD, Tussinate)?

If you experience any of the following serious side effects, stop taking diphenhydramine, hydrocodone, and phenylephrine and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); or
  • confusion, hallucinations, or unusual behavior.

Other, less serious side effects may be more likely to occur. Continue to take diphenhydramine, hydrocodone, and phenylephrine and talk to your doctor if you experience

  • dizziness, drowsiness, or sleepiness;
  • restlessness or irritability;
  • blurred vision;
  • constipation;
  • dry mouth, nausea, vomiting, or decreased appetite;
  • muscle twitches;
  • sweating;
  • itching;
  • decreased urination;
  • increased sensitivity to sunlight.

Hydrocodone is habit forming. It is possible become physically and/or psychologically dependent on the medication. Do not take more than the prescribed amount of medication or take it for longer than is directed by your doctor. Withdrawal effects may occur if diphenhydramine, hydrocodone, and phenylephrine is stopped suddenly after several weeks of continuous use. Your doctor may recommend a gradual reduction in dose.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about diphenhydramine, hydrocodone, and phenylephrine (Endal HD, Tussinate)?

Use caution when driving, operating machinery, or performing other hazardous activities. Diphenhydramine, hydrocodone, and phenylephrine may cause dizziness or drowsiness. If you experience dizziness or drowsiness, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking diphenhydramine, hydrocodone, and phenylephrine.

Diphenhydramine, hydrocodone, and phenylephrine may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, seizure medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any other medicine without first talking to your doctor.

Hydrocodone is habit forming. It is possible become physically and/or psychologically dependent on the medication. Do not take more than the prescribed amount of medication or take it for longer than is directed by your doctor. Withdrawal effects may occur if diphenhydramine, hydrocodone, and phenylephrine is stopped suddenly after several weeks of continuous use. Your doctor may recommend a gradual reduction in dose.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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