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What should I discuss with my healthcare provider before taking diphenhydramine, hydrocodone, and phenylephrine (Endal HD, Tussinate)?

Do not take diphenhydramine, hydrocodone, and phenylephrine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Before taking diphenhydramine, hydrocodone, and phenylephrine, tell your doctor if you have

• epilepsy or another seizure disorder;
• been diagnosed with sleep apnea (periods of not breathing during sleep);
• thyroid problems;
• asthma;
• gallbladder disease;
• a head injury;
• Addison's disease;
• diabetes;
• glaucoma;
• an ulcer or an obstruction in the stomach;
• bladder problems or difficulty urinating;
• an enlarged prostate;
• high blood pressure, irregular heartbeats, or any type of heart disease;
• kidney problems; or
• liver problems.

You may not be able to take diphenhydramine, hydrocodone, and phenylephrine, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Diphenhydramine, hydrocodone, and phenylephrine is in the FDA pregnancy category C. This means that it is not known whether diphenhydramine, hydrocodone, and phenylephrine will be harmful to an unborn baby. Do not take diphenhydramine, hydrocodone, and phenylephrine without first talking to your doctor if you are pregnant or could become pregnant during treatment.

It is not known whether diphenhydramine, hydrocodone, and phenylephrine passes into breast milk. Do not take diphenhydramine, hydrocodone, and phenylephrine without first talking to your doctor if you are breast-feeding a baby.

If you are over 60 years of age, you may be more likely to experience side effects from diphenhydramine, hydrocodone, and phenylephrine. Your doctor may prescribe a lower dose of this medication.

How should I take diphenhydramine, hydrocodone, and phenylephrine (Endal HD, Tussinate)?

Take diphenhydramine, hydrocodone, and phenylephrine exactly as directed by your doctor. If you do not understand the directions on your prescription bottle, ask your pharmacist, nurse, or doctor to explain the instructions to you.

Diphenhydramine, hydrocodone, and phenylephrine can be taken with or without food.

To ensure that you get a correct dose, measure the liquid form of diphenhydramine, hydrocodone, and phenylephrine with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.

Store diphenhydramine, hydrocodone, and phenylephrine at room temperature away from moisture and heat.

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