What happens if I miss a dose (Tikosyn)?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose (Tikosyn)?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include some of the serious side effects listed in this medication guide.
What should I avoid while taking dofetilide (Tikosyn)?
Grapefruit and grapefruit juice may interact with dofetilide and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
What other drugs will affect dofetilide (Tikosyn)?
Many drugs can interact with dofetilide. Below is just a partial list. Tell your doctor if you are using:
- arsenic trioxide (Trisenox);
- conivaptan (Vaprisol);
- imatinib (Gleevec);
- isoniazid (for treating tuberculosis);
- tacrolimus (Prograf);
- an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), levofloxacin (Levaquin), moxifloxacin (Avelox), or pentamidine (NebuPent, Pentam);
- an antidepressant such as amitriptylline (Elavil, Vanatrip, Limbitrol), clomipramine (Anafranil), desipramine (Norpramin), fluvoxamine (Luvox), sertraline (Zoloft), and others;
- antifungal medicine such as itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);
- anti-malaria medications such as chloroquine (Aralen) or mefloquine (Lariam);
- a diuretic (water pill) such as amiloride amiloride (Midamor), triamterene triamterene (Dyrenium), and others;
- heart rhythm medicine such as amiodarone (Cordarone, Pacerone), diltiazem (Cartia, Cardizem), disopyramide (Norpace), dronedarone (Multaq), ibutilide (Corvert), nicardipine (Cardene), procainamide (Procan, Pronestyl), propafenone (Rythmol), quinidine (Quin-G), or sotalol (Betapace);
- HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir, Kaletra);
- medicine to prevent or treat nausea and vomiting such as dolasetron (Anzemet), droperidol (Inapsine), or ondansetron (Zofran);
- medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), clozapine (FazaClo, Clozaril), haloperidol (Haldol), pimozide (Orap), thioridazine (Mellaril), or ziprasidone (Geodon);
- migraine headache medicine such as sumatriptan (Imitrex, Treximet) or zolmitriptan (Zomig);
- narcotic medication such as methadone (Methadose, Diskets, Dolophine); or
- oral diabetes medications that contain metformin (Actoplus Met, Avandamet, Glucophage, Glucovance, Janumet, Kombiglyze, Metaglip, Prandimet).
This list is not complete and other drugs may interact with dofetilide. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Where can I get more information?
Your doctor or pharmacist can provide more information about dofetilide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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