Medications and Drugs

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Brand Names: Adapin, Sinequan

Generic Name: doxepin (Pronunciation: DOX e pin)

• What is doxepin (Adapin, Sinequan)?
• What are the possible side effects of doxepin (Adapin, Sinequan)?
• What is the most important information I should know about doxepin (Adapin, Sinequan)?
• What should I discuss with my healthcare provider before taking doxepin (Adapin, Sinequan)?
• How should I take doxepin (Adapin, Sinequan)?
• What happens if I miss a dose (Adapin, Sinequan)?
• What happens if I overdose (Adapin, Sinequan)?
• What should I avoid while taking doxepin (Adapin, Sinequan)?
• What other drugs will affect doxepin (Adapin, Sinequan)?
• Where can I get more information?

What is doxepin (Adapin, Sinequan)?

Doxepin is in a group of drugs called tricyclic antidepressants. Doxepin affects chemicals in the brain that may become unbalanced.

Doxepin is used to treat symptoms of depression and/or anxiety associated with alcoholism, psychiatric conditions, or manic-depressive conditions.

Doxepin may also be used for other purposes not listed in this medication guide.

Doxepin 10 mg-MYL

white, imprinted with MYLAN 1049

Doxepin 10 mg-PAR

white, imprinted with par 217

Doxepin 10 mg-WAT

beige, imprinted with DAN 5629

Doxepin 100 mg-MYL

green/white, imprinted with MYLAN 6410

Doxepin 100 mg-PAR

green/white, imprinted with par 221

Doxepin 100 mg-WAT

green/white, imprinted with DAN 5633

Doxepin 150 mg-PAR

blue/white, imprinted with par 222

Doxepin 25 mg-MYL

white/yellow, imprinted with MYLAN 3125

Doxepin 25 mg-PAR

white/yellow, imprinted with par 218

Doxepin 25 mg-WAT

white/yellow, imprinted with DAN 5630

Doxepin 50 mg-MYL

yellow, imprinted with MYLAN 4250

Doxepin 50 mg-PAR

beige, imprinted with par 219

Doxepin 50 mg-WAT

yellow, imprinted with DAN 5631

Doxepin 75 mg-MYL

green, imprinted with MYLAN 5375

Doxepin 75 mg-PAR

green, imprinted with par 220

Doxepin 75 mg-WAT

green, imprinted with DAN 5632

What are the possible side effects of doxepin (Adapin, Sinequan)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

• fast, pounding, or uneven heart rate;
• confusion, hallucinations, or seizure (convulsions);
• easy bruising or bleeding, unusual weakness;
• feeling light-headed, fainting;
• restless muscle movements in your eyes, tongue, jaw, or neck;
• tremors or uncontrollable shaking;
• urinating less than usual or not at all; or
• extreme thirst with headache, nausea, vomiting, and weakness.

Less serious side effects may include:

• nausea, vomiting, constipation, loss of appetite;
• dry mouth;
• weight changes;
• weakness, lack of coordination;
• numbness or tingly feeling;
• feeling dizzy, drowsy, or tired;
• sleep problems (insomnia), nightmares;
• blurred vision, headache, ringing in your ears;
• increased sweating;
• breast swelling (in men or women); or
• decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about doxepin (Adapin, Sinequan)?

Do not use this medication if you are allergic to doxepin, or if you have glaucoma or problems with urination.

Do not use doxepin if you have used an MAO inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate) within the past 14 days. Serious, life-threatening side effects can occur if you take doxepin before the MAO inhibitor has cleared from your body.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.