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Medications and Drugs

Brand Names: Silenor

Generic Name: doxepin (Silenor) (Pronunciation: DOX e pin)

What is doxepin (Silenor) (Silenor)?

Doxepin (Silenor) is in a group of drugs called hypnotics.

Doxepin (Silenor) is used to treat insomnia in people who have trouble staying asleep.

Doxepin may also be used for purposes not listed in this medication guide.

What are the possible side effects of doxepin (Silenor) (Silenor)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a side effect such as:

  • fast, pounding, or uneven heart rate;
  • confusion, hallucinations, unusual thoughts or behavior, seizure (convulsions);
  • new or worsening symptoms of depression (mood or behavior changes, anxiety, trouble sleeping, feeling agitated, thoughts about suicide or hurting yourself.
  • easy bruising or bleeding, unusual weakness;
  • feeling light-headed, fainting;
  • restless muscle movements in your eyes, tongue, jaw, or neck;
  • tremors or uncontrollable shaking;
  • urinating less than usual or not at all; or
  • extreme thirst with headache, nausea, vomiting, and weakness.

Other common side effects may include:

  • drowsiness, dizziness;
  • cold symptoms such as stuffy nose, sneezing, sore throat;
  • nausea, vomiting, diarrhea, constipation, loss of appetite;
  • dry mouth;
  • weight changes;
  • lack of coordination;
  • numbness or tingly feeling;
  • strange dreams;
  • blurred vision, headache, ringing in your ears;
  • increased sweating;
  • breast swelling (in men or women); or
  • decreased sex drive, impotence, or difficulty having an orgasm.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about doxepin (Silenor) (Silenor)?

You should not use this medication if you have untreated narrow-angle glaucoma or severe problems with urination. Do not use if you are allergic to doxepin or to similar medications such as amitriptyline, amoxapine, clomipramine, desipramine, imipramine, nortriptyline, protriptyline, or trimipramine.

Do not use doxepin if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include furazolidone, isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine.

Some people using this medicine have engaged in activity such as driving, eating, or making phone calls and later having no memory of the activity. If this happens to you, stop taking doxepin and talk with your doctor.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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