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Medications and Drugs

Brand Names: COPD, Difil G, Difil-G Forte, Dilex-G, Dilex-G 200, Dyflex-G, Dy-G, Dyphylline GG, Dyphylline GG ES, Dyphyllin-GG, Jay-Phyl, Lufyllin-GG, Panfil G

Generic Name: dyphylline and guaifenesin (Pronunciation: DYE fil in and gwye FEN e sin)

What is dyphylline and guaifenesin (COPD, Difil G, Difil-G Forte, Dilex-G, Dilex-G 200, Dyflex-G, Dy-G, Dyphylline GG, Dyphylline GG ES, Dyphyllin-GG, Jay-Phyl, Lufyllin-GG, Panfil G)?

Dyphylline is a bronchodilator. It works by relaxing muscles in the airways to improve breathing.

Guaifenesin is an expectorant. It helps loosen congestion in your chest and throat, making it easier to cough out through your mouth.

The combination of dyphylline and guaifenesin is used to treat cough and breathing problems caused by bronchial asthma, chronic bronchitis, or emphysema. This medication is not a cure for asthma, bronchitis, or emphysema.

Dyphylline and guaifenesin may also be used for purposes not listed in this medication guide.

What are the possible side effects of dyphylline and guaifenesin?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • fast, pounding, or uneven heartbeats;
  • rapid breathing;
  • muscle twitching;
  • feeling like you might pass out;
  • seizure (convulsions); or
  • extreme thirst with headache, nausea, vomiting, and weakness.

Less serious side effects may include:

  • headache;
  • mild nausea, vomiting, or stomach pain;
  • feeling restless, agitated, or irritable;
  • sleep problems (insomnia); or
  • warmth, redness, or tingly feeling under your skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about dyphylline and dyphylline and guaifenesin?

You should not use this medicine if you are allergic to dyphylline or guaifenesin. This medication will not treat an asthma attack.

Before taking this medication, tell your doctor if you have heart disease or a history of heart attack, high blood pressure, overactive thyroid, or a stomach ulcer.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication.

Ask a doctor or pharmacist before using any other cough or cold medicine. Guaifenesin is contained in many combination medicines. Taking certain products together can cause you to get too much guaifenesin. Check the label to see if a medicine contains guaifenesin.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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