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Medications and Drugs

Brand Names: Atripla

Generic Name: efavirenz, emtricitabine, and tenofovir (Pronunciation: ef AV ir enz, em trye SYE ta been, and ten OF oh vir)

What is efavirenz, emtricitabine, and tenofovir (Atripla)?

Efavirenz, emtricitabine, and tenofovir is an antiviral medication that prevents human immunodeficiency virus (HIV) from reproducing in your body.

Efavirenz, emtricitabine, and tenofovir treats HIV, which causes acquired immunodeficiency syndrome (AIDS). This medication is not a cure for HIV or AIDS.

Efavirenz, emtricitabine, and tenofovir may also be used for purposes not listed in this medication guide.

What are the possible side effects of efavirenz, emtricitabine, and tenofovir (Atripla)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

This medication may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, fast or uneven heart rate, dizziness, or feeling very weak or tired.

Stop using this medication and call your doctor at once if you have any other serious side effects such as:

  • signs of liver damage - nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • urinating less than usual or not at all;
  • fever, chills, body aches, flu symptoms;
  • unusual thoughts or behavior, anger, severe depression, thoughts of hurting yourself or others, hallucinations;
  • severe blistering, peeling, and red skin rash; or
  • seizure (convulsions).

Less serious side effects may include:

  • mild nausea, vomiting, diarrhea, gas, upset stomach;
  • headache, dizziness, drowsiness, tired feeling;
  • trouble concentrating;
  • sleep problems (insomnia), strange dreams;
  • darkened skin on the palms of your hands or the soles of your feet; or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about efavirenz, emtricitabine, and tenofovir (Atripla)?

Do not take this medication if you are also taking cisapride (Propulsid), midazolam (Versed), triazolam (Halcion), St. John's wort, voriconazole (Vfend), or an ergot medicine such as dihydroergotamine (D.H.E. 45, Migranal), ergonovine (Ergotrate), ergotamine (Ergomar), or methylergonovine (Methergine). Do not take this medication with other medicines that also contain efavirenz, emtricitabine, or tenofovir (Complera, Sustiva, Emtriva, Truvada, Viread), or lamivudine (Combivir, Epivir, Epzicom, Trizivir).

There are many other drugs that can cause serious or life-threatening medical problems if you take them together with efavirenz, emtricitabine, and tenofovir. Tell your doctor about all medications you use.

Some people develop lactic acidosis while taking efavirenz, emtricitabine, and tenofovir. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, fast or uneven heart rate, dizziness, or feeling very weak or tired.

Efavirenz, emtricitabine, and tenofovir can cause severe or fatal liver problems. Call your doctor at once if you have symptoms such as nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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