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Brand Names: Integrilin

Generic Name: eptifibatide (Pronunciation: ep ti FYE ba tide)

• What is eptifibatide (Integrilin)?
• What are the possible side effects of eptifibatide (Integrilin)?
• What is the most important information I should know about eptifibatide (Integrilin)?
• What should I discuss with my health care provider before receiving eptifibatide (Integrilin)?
• How is eptifibatide given (Integrilin)?
• What happens if I miss a dose (Integrilin)?
• What happens if I overdose (Integrilin)?
• What should I avoid while receiving eptifibatide (Integrilin)?
• What other drugs will affect eptifibatide (Integrilin)?
• Where can I get more information?

What is eptifibatide (Integrilin)?

Eptifibatide keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions.

Eptifibatide is used to prevent blood clots or heart attack in people with severe chest pain or other conditions, and in those who are undergoing a procedure called angioplasty (to open blocked arteries).

Eptifibatide may also be used for purposes not listed in this medication guide.

What are the possible side effects of eptifibatide (Integrilin)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

• easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
• blood in your urine;
• black, bloody, or tarry stools;
• coughing up blood or vomit that looks like coffee grounds;
• any bleeding that will not stop;
• sudden numbness or weakness, especially on one side of the body;
• sudden severe headache, confusion, problems with vision, speech, or balance;
• fever, chills, body aches, flu symptoms; or
• feeling like you might pass out.

Less serious side effects may also occur, such as:

• nausea;
• upset stomach; or
• bleeding around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about eptifibatide (Integrilin)?

You should not receive this medication if you are allergic to eptifibatide, if you have or will soon receive treatment with similar medications such as abciximab (ReoPro) or tirofiban (Aggrastat).

You should not receive this medication if you have severe or uncontrolled high blood pressure, if you are on dialysis due to kidney failure, history of a bleeding or blood clotting disorder, if you had a stroke or any type of bleeding within the past 30 days, or if you had any type of surgery, injury, or medical emergency within the past 6 weeks.

Eptifibatide is not expected to be harmful to an unborn baby. However, aspirin is sometimes given with eptifibatide, and aspirin can cause bleeding when it is taken during the last 3 months of pregnancy. Aspirin can also cause side effects in a newborn baby.

Tell your doctor if you are pregnant or plan to become pregnant during treatment with eptifibatide and aspirin.

Because eptifibatide keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.

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