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What should I discuss with my healthcare provider before taking estramustine (Emcyt)?

You should not use this medication if you are allergic to estramustine, or if you have:

• a blood clot;
• swelling of a vein caused by a blood clot; or
• if you have ever had an allergic reaction to estradiol or nitrogen mustard.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take estramustine:

• a history of blood clot, stroke, or heart attack;
• diabetes;
• high blood pressure (hypertension);
• heart disease or coronary artery disease (atherosclerosis);
• congestive heart failure;
• migraine headaches;
• epilepsy or other seizure disorder;
• liver disease;
• kidney disease; or
• a metabolic bone disease (such as Paget's disease).

If a man fathers a child while taking estramustine, the baby may have birth defects. Use a condom to prevent pregnancy during your treatment. Ask your doctor how long you should continue using condoms after you stop taking estramustine.

How should I take estramustine (Emcyt)?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Take estramustine on an empty stomach, at least 1 hour before or 2 hours after a meal.

Take this medication with water, not with milk or other dairy products.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your blood pressure may also need to be checked. Do not miss any scheduled appointments.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using estramustine.

Store estramustine capsules in the refrigerator and do not allow it to freeze.

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