Medications and Drugs

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Brand Names: Lodine, Lodine XL

Generic Name: etodolac (Pronunciation: ee toe DOE lak)

• What is etodolac (Lodine, Lodine XL)?
• What are the possible side effects of etodolac (Lodine, Lodine XL)?
• What is the most important information I should know about etodolac (Lodine, Lodine XL)?
• What should I discuss with my healthcare provider before taking etodolac (Lodine, Lodine XL)?
• How should I take etodolac (Lodine, Lodine XL)?
• What happens if I miss a dose (Lodine, Lodine XL)?
• What happens if I overdose (Lodine, Lodine XL)?
• What should I avoid while taking etodolac (Lodine, Lodine XL)?
• What other drugs will affect etodolac (Lodine, Lodine XL)?
• Where can I get more information?

What is etodolac (Lodine, Lodine XL)?

Etodolac is in a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Etodolac works by reducing hormones that cause inflammation and pain in the body.

Etodolac is used to treat pain or inflammation caused by arthritis.

Etodolac may also be used for other purposes not listed in this medication guide.

Etodolac 200 mg-APO

gray/white, imprinted with APO, 039

Etodolac 200 mg-ESI

white, imprinted with 59911 3606, 200

Etodolac 200 mg-TAR

pink, imprinted with ETO 200 MG

Etodolac 300 mg-APO

gray/white, imprinted with APO, 040

Etodolac 300 mg-ESI

white, imprinted with 59911 3607, 300

Etodolac 300 mg-TAR

pink, imprinted with ETO 300 MG

Etodolac 300 mg-TEV

red, imprinted with N 397 300, striped

Etodolac 400 mg ER-TEV

oblong, orange, imprinted with 93, 1122

Etodolac 400 mg-APO

oblong, white, imprinted with 400, APO 041

Etodolac 400 mg-ESI

oblong, white, imprinted with 59911, 3608

Etodolac 400 mg-TAR

oblong, peach, imprinted with T 88

Etodolac 400 mg-TEV

oblong, pink, imprinted with 93, 892

Etodolac 500 mg ER-TEV

oblong, gray, imprinted with 93, 7172

Etodolac 500 mg-EON

oval, white, imprinted with E139

Etodolac 500 mg-PAR

oval, blue, imprinted with G, ET 500

Etodolac 500 mg-TAR

oblong, green, imprinted with T500

Etodolac 600 mg ER-TEV

oblong, blue, imprinted with 93, 1118

Etodolac ER 400 mg-TAR

round, pink, imprinted with T400

Etodolac ER 500 mg-TAR

oblong, green, imprinted with T500

Etodolac ER 600 mg-TAR

oval, gray, imprinted with T600

Lodine 300 mg

gray, imprinted with LODINE 300

Lodine 400 mg

oblong, orange, imprinted with LODINE 400

Lodine XL 500 mg

oval, green, imprinted with LODINE XL 500

What are the possible side effects of etodolac (Lodine, Lodine XL)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking etodolac and seek medical attention or call your doctor at once if you have any of these serious side effects:

• chest pain, weakness, shortness of breath, slurred speech, problems with vision or balance;
• black, bloody, or tarry stools;
• coughing up blood or vomit that looks like coffee grounds;
• swelling or rapid weight gain;
• urinating less than usual or not at all;
• nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;
• bruising, severe tingling, numbness, pain, muscle weakness; or
• fever, headache, neck stiffness, chills, increased sensitivity to light, purple spots on the skin, and/or seizure (convulsions).

Less serious side effects may include:

• upset stomach, mild heartburn or stomach pain, diarrhea, constipation;
• bloating, gas;
• dizziness, headache, nervousness;
• skin itching or rash;
• sore throat, stuffy nose;
• blurred vision; or
• ringing in your ears.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about etodolac (Lodine, Lodine XL)?

This medicine can increase your risk of life-threatening heart or circulation problems, including heart attack or stroke. This risk will increase the longer you use etodolac. Do not use this medicine just before or after having heart bypass surgery (also called coronary artery bypass graft, or CABG).

Seek emergency medical help if you have symptoms of heart or circulation problems, such as chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.

This medicine can also increase your risk of serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and gastrointestinal effects can occur without warning at any time while you are taking etodolac. Older adults may have an even greater risk of these serious gastrointestinal side effects.

Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.

Do not use any other over-the-counter cold, allergy, or pain medication without first asking your doctor or pharmacist. Many medicines available over the counter contain aspirin or other medicines similar to etodolac (such as ibuprofen, ketoprofen, or naproxen). If you take certain products together you may accidentally take too much of this type of medication. Read the label of any other medicine you are using to see if it contains aspirin, ibuprofen, ketoprofen, or naproxen.

Do not drink alcohol while taking etodolac. Alcohol can increase the risk of stomach bleeding caused by etodolac.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Etodolac can make your skin more sensitive to sunlight and sunburn may result.