Medications and Drugs
Brand Names: Vytorin
Generic Name: ezetimibe and simvastatin (Pronunciation: ez ET i mibe and SIM va stat in)
What is ezetimibe and simvastatin (Vytorin)?
Ezetimibe reduces the amount of cholesterol absorbed by the body.
Ezetimibe and simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Ezetimibe and simvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).
The combination of ezetimibe and simvastatin is used to treat high cholesterol in adults and children who are at least 10 years old.
Ezetimibe and simvastatin may also be used for purposes not listed in this medication guide.
Vytorin 10-10 mg
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Vytorin 10-20 mg
oval, white, imprinted with 312
Vytorin 10-40 mg
oval, white, imprinted with 313
Vytorin 10-80 mg
oval, white, imprinted with 315
What are the possible side effects of ezetimibe and simvastatin (Vytorin)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking ezetimibe and simvastatin and call your doctor at once if you have any of these serious side effects:
Less serious side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about ezetimibe and simvastatin (Vytorin)?
You should not take ezetimibe and simvastatin if you are allergic to it, if you have liver disease, or if you are pregnant or breast-feeding.
In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Never take ezetimibe and simvastatin in larger amounts, or for longer than recommended by your doctor. Follow your doctor's dosing instructions very carefully. Taking too much of this medication may cause serious or life-threatening side effects.
There are many other drugs that should not be used together with ezetimibe and simvastatin. Tell your doctor about all medications you use. Keep a list of all your medicines and show it to any healthcare provider who treats you.
Before taking ezetimibe and simvastatin, tell your doctor if you have ever had liver or kidney disease, diabetes, or a thyroid disorder, if you are of Chinese descent, or if you drink more than 2 alcoholic beverages daily.
This medicine can harm an unborn baby or cause birth defects. Do not use if you are pregnant.
Grapefruit and grapefruit juice may interact with simvastatin and lead to potentially dangerous effects. Do not drink more than 1 quart of grapefruit juice daily.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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