Medications and Drugs
Brand Names: Duexis
Generic Name: famotidine and ibuprofen (Pronunciation: fam OH ti deen and EYE bue PROE fen)
What is famotidine and ibuprofen (Duexis)?
Famotidine is a histamine blocker. Famotidine works by decreasing the amount of acid the stomach produces.
Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ibuprofen works by reducing hormones that cause inflammation and pain in the body.
Famotidine and ibuprofen is a combination drug. Ibuprofen treats the symptoms of arthritis. Famotidine helps reduce the risk of ulcers in the stomach or intestines that can be caused by long-term use of ibuprofen.
Famotidine and ibuprofen may also be used for purposes not listed in this medication guide.
What are the possible side effects of famotidine and ibuprofen (Duexis)?
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop taking famotidine and ibuprofen and seek medical attention or call your doctor at once if you have any of these serious side effects:
Less serious side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What is the most important information I should know about famotidine and ibuprofen (Duexis)?
You should not use this medication if you are allergic to ibuprofen (Advil, Motrin), famotidine (Pepcid), aspirin, other NSAIDs (non-steroidal anti-inflammatory drugs), or other stomach acid reducers (such as Tagamet, Zantac, or Axid).
Before you take this medicine, tell your doctor if you have a stomach or intestinal disorder, heart disease, high blood pressure, asthma, nasal polyps, liver or kidney disease, lupus, a bleeding or blood-clotting disorder, or a history of heart attack, stroke, or blood clot. Also tell your doctor if you smoke.
Ibuprofen may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term. Do not use famotidine and ibuprofen just before or after heart bypass surgery (coronary artery bypass graft, or CABG).
Get emergency medical help if you have chest pain, weakness, shortness of breath, slurred speech, or problems with vision or balance.
Ibuprofen may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning, especially in older adults.
Call your doctor at once if you have symptoms of stomach bleeding such as black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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