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famotidine and ibuprofen (cont.)

What should I discuss with my healthcare provider before taking famotidine and ibuprofen (Duexis)?

Do not use famotidine and ibuprofen just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Ibuprofen may cause life-threatening heart or circulation problems such as heart attack or stroke, especially if you use it long term.

Ibuprofen may also cause serious effects on the stomach or intestines, including bleeding or perforation (forming of a hole). These conditions can be fatal and can occur without warning, especially in older adults.

You should not use this medication if you are allergic to ibuprofen (Advil, Motrin) or famotidine (Pepcid), or if you have:

To make sure you can safely take famotidine and ibuprofen, tell your doctor if you have any of these other conditions:

Famotidine and ibuprofen can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

FDA pregnancy category C. Do not take this medicine if you are more than 7 months pregnant. Taking ibuprofen during this time may harm the unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using famotidine and ibuprofen.

Do not give this medicine to a child without the advice of a doctor.

How should I take famotidine and ibuprofen (Duexis)?

Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Famotidine and ibuprofen is usually taken 3 times each day. Follow your doctor's instructions.

Do not take more of this medication than is recommended. An overdose of ibuprofen can cause damage to your stomach or intestines. The maximum amount of ibuprofen for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Use only the smallest amount of ibuprofen needed to get relief from your pain, swelling, or fever.

Do not crush, chew, or break a famotidine and ibuprofen tablet. Swallow it whole.

If you have hypertension, your blood pressure will need to be checked often. If you use this medication long-term, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Visit your doctor regularly.

If you also use a steroid medication, do not stop using it suddenly or you may have unpleasant withdrawal symptoms. Talk with your doctor about using less and less of the steroid before stopping completely.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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