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What should I discuss with my health care provider before receiving flumazenil (Romazicon)?

You should not receive this medication if you are allergic to flumazenil or any type of benzodiazepine sedative, or if you have taken an overdose of antidepressant medication such as Elavil, Janimine, Tofranil, Norpramin, Desyrel, Ascendin, Anafranil, Sinequan, Pamelor, Vivactil, or Surmontil.

Before receiving flumazenil, tell your doctor if you are allergic to any drugs, or if you have:

• epilepsy or other seizure disorder;
• liver disease;
• a history of head injury;
• uncontrolled muscle twitches;
• asthma or other breathing disorder;
• panic or anxiety disorder; or
• a history of drug or alcohol addiction.

If you have any of these conditions, you may not be able to use flumazenil, or you may need dosage adjustments or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether flumazenil passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How is flumazenil given (Romazicon)?

Flumazenil is given as an injection through a needle placed into a vein. You will receive this injection in a hospital or surgical clinic.

Flumazenil is usually effective in reversing sedation within 2 hours.

You may have temporary amnesia while you are coming out of sedation after a surgery. You may not remember everything going on around you during this time.

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