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Medications and Drugs

Brand Names: Symbyax

Generic Name: fluoxetine and olanzapine (Pronunciation: floo OX eh teen and oh LAN za peen)

What is fluoxetine and olanzapine (Symbyax)?

Fluoxetine is an antidepressant in a group of drugs called selective serotonin reuptake inhibitors (SSRIs).

Olanzapine is an antipsychotic medication. These drugs affect chemicals in the brain.

The combination of fluoxetine and olanzapine is used to treat depression caused by bipolar disorder (manic depression). Fluoxetine and olanzapine is also used to treat depression after at least 2 other medications have been tried without successful treatment of symptoms.

Fluoxetine and olanzapine may also be used for other purposes not listed in this medication guide.

Symbyax 12-25 mg

capsule, red/yellow, imprinted with Lilly 3232, 12/25

Symbyax 25 mg-6 mg

capsule, yellow, imprinted with Lilly 3231, 6/25

Symbyax 3 mg-25 mg

capsule, pink/yellow, imprinted with Lilly 3230, 3/25

Symbyax 50 mg-12 mg

capsule, gray/red, imprinted with Lilly 3234, 12/50

Symbyax 50 mg-6 mg

capsule, gray/yellow, imprinted with Lilly 3233, 6/50

What are the possible side effects of fluoxetine and olanzapine (Symbyax)?

Get emergency medical help if you have any of these signs of an allergic reaction: skin rash or hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have a serious side effect such as:

  • sudden and severe headache, chest pain, numbness, and problems with vision, speech, or balance;
  • increased thirst, frequent urination, excessive hunger, or weakness;
  • agitation, hallucinations, fever, fast heart rate, overactive reflexes, vomiting, diarrhea, loss of coordination;
  • very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out;
  • jerky muscle movements you cannot control, seizure (convulsions);
  • feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
  • flu symptoms, easy bruising, sores in your mouth and throat; or
  • seizure (convulsions);
  • nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • dry mouth, increased appetite, weight gain;
  • feeling drowsy or tired;
  • blurred vision; or
  • swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about fluoxetine and olanzapine (Symbyax)?

This medication is not for use in psychotic conditions related to dementia. Olanzapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions.

Do not use this medication together with pimozide (Orap) or thioridazine (Mellaril), or if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. A dangerous drug interaction could occur, leading to serious side effects.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

SSRI antidepressants may cause serious or life-threatening lung problems in newborn babies whose mothers take the medication during pregnancy. However, you may have a relapse of depression if you stop taking your antidepressant during pregnancy. If you become pregnant while taking fluoxetine and olanzapine, do not stop taking it without your doctor's advice.



Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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