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What should I discuss with my healthcare provider before using fondaparinux (Arixtra)?
You should not use this medication if you are allergic to fondaparinux, heparin, or pork products, or if you have:
You should not use fondaparinux to prevent blood clots after surgery if you weigh less than 110 pounds (50 kilograms).
Fondaparinux may cause you to bleed more easily, especially if you have:
Fondaparinux can cause a very serious blood clot around your brain or spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural). This type of blood clot could cause long-term paralysis, and may be more likely to occur if you have:
FDA pregnancy category B. Fondaparinux is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
It is not known whether fondaparinux passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I use fondaparinux (Arixtra)?
Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Fondaparinux is usually given every day until your bleeding condition improves. Follow the directions on your prescription label.
Fondaparinux is injected under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.
You should be sitting or lying down during the injection. Do not inject fondaparinux into a muscle or a vein.
Prepare your dose in a syringe only when you are ready to give yourself an injection. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.
Use a different place on your stomach each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row.
Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.
Tell any doctor who treats you that you are using fondaparinux. If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are using this medication.
To be sure this medication is not causing harmful effects, your blood and your stool (bowel movement) may need to be tested often. Your nerve and muscle function may also need to be tested. Visit your doctor regularly.
Store at room temperature away from moisture and heat. Do not freeze.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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