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What should I discuss with my healthcare provider before using fondaparinux (Arixtra)?

You should not use this medication if you are allergic to fondaparinux, heparin, or pork products, or if you have:

• active or uncontrolled bleeding;
• severe kidney disease;
• an infection in the lining of your heart (also called bacterial endocarditis); or
• a low level of platelets in your blood after testing positive for a certain antibody while using fondaparinux.

You should not use fondaparinux to prevent blood clots after surgery if you weigh less than 110 pounds (50 kilograms).

Fondaparinux may cause you to bleed more easily, especially if you have:

• a bleeding disorder that is inherited or caused by disease;
• hemorrhagic stroke;
• eye problems caused by diabetes;
• uncontrolled high blood pressure;
• stomach or intestinal bleeding or ulcer;
• recent brain, spine, or eye surgery; or
• kidney disease (especially if you are an older adult).

• a genetic spinal defect;
• a history of spinal surgery or repeated spinal taps; or
• if you are using other medications to treat or prevent blood clots.

FDA pregnancy category B. Fondaparinux is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether fondaparinux passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use fondaparinux (Arixtra)?

Fondaparinux is injected under the skin. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes.

You should be sitting or lying down during the injection. Do not inject fondaparinux into a muscle or a vein.

Use a different place on your stomach each time you give the injection. Your care provider will show you the best places on your body to inject the medication. Do not inject into the same place two times in a row.

Prepare your dose in a syringe only when you are ready to give yourself an injection. Do not use the medication if it has changed colors or has particles in it. Call your doctor for a new prescription.

Use a disposable needle only once. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Fondaparinux is usually given every day until your bleeding condition improves. Follow your doctor's instructions.

To be sure this medication is not causing harmful effects, your blood and your stool (bowel movement) may need to be tested often. Your nerve and muscle function may also need to be tested. Visit your doctor regularly.

Tell any doctor who treats you that you are using fondaparinux. If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are using this medication.

Store at room temperature away from moisture and heat. Do not freeze.

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